Biologist and paleontologists are all familiar with the name of Lynn Margulis. Now 73, she made her reputation in the 1960s for her “endosymbiosis” hypothesis: the idea that complex eukaryotic cells with all their organelles were assembled from prokaryotes which came to live symbiotically within the walls of other prokaryotic cells. Her hypothesis was first proposed by Merezhovsky in 1905 and Wallin in 1920, but Margulis used the great advances in microscopy and microbiology in the 1960s to show that the idea was highly plausible. At first, her papers were rejected by at least 15 journals before they were finally published. But as time passed, the evidence for much of her “outrageous idea” continued to accumulate. It does indeed appear that the chloroplasts of the eukaryotic cell are derived from symbiotic cyanobacteria (as it is common that many animals, from large benthic foraminifera to hermatypic corals to giant clams, use algae in their own tissues symbiotically), and that mitochondria were once purple non-sulfur bacteria. The best evidence comes from the fact that organelles have their own DNA independent of the cell’s nuclear DNA (we hear about research on mitochondrial DNA all the time); that organelles can divide independently of their host cell and have their own ribosomes; that organelles can be killed by antibiotics, just like their prokaryote ancestors, while the host cell is not killed. In addition, there are now numerous examples of eukaryotes which still use endosymbiotic prokaryotes to perform various functions, and have not completely absorbed and transformed them into organelles of the host cell. Over the years, Margulis has promoted additional ideas about the importance of symbiosis in biology, and has become a major advocate of the “Gaia” hypothesis and how all of life is dependent on the rest of life in an intricate, delicate web.
Margulis’ sheer determination in getting her ideas heard, and finding scientific evidence to support them, was remarkable, especially in a age where the idea was highly unorthodox. But she was never an orthodox scientist to begin with. Admitted to the University of Chicago when she was 14, she married Carl Sagan when she was 19, and her son Dorion Sagan is a frequent coauthor with her on her books. Her other child with the great astronomer, Jeremy Sagan, is a software developer and the founder of Sagan Technology. As the years go by and more and more people recognize her pioneering work, she has received all sorts of honors: membership of the National Academy of Sciences in 1983, the 1999 National Medal of Science, the 2008 Darwin-Wallace Medal, the William Procter Prize for Scientific Achievement, and her papers are archived at the Library of Congress. (continue reading…)